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Título : Protocol for studying cough frequency in people with pulmonary tuberculosis
Autor : Proaño, Alvaro
Bravard, Marjory A
Tracey, Brian H
López, José W
Comina, German
Zimic, Mirko
Coronel, Jorge
O’Neill Lee, Gwenyth
Caviedes, Luz
Cabrera, Jose Luis
Salas, Antonio
Ticona, Eduardo
Kirwan, Daniela E
Friedland, Jon S
Evans, Carlton A
Moore, David A
Gilman, Robert H
Tuberculosis Working Group in Peru
Palabras clave : Cough;Monitoring;Tuberculosis Working Group in Peru;Pulmonary tuberculosis
Fecha de publicación : may-2016
Editorial : BMJ Publishing Group
URI Relacionado: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84970969697&doi=10.1136%2fbmjopen-2015-010365&partnerID=40&md5=27a1f88231af843b8ea3efe49fddfc9e
Resumen : Introduction: Cough is a key symptom of tuberculosis (TB) as well as the main cause of transmission. However, a recent literature review found that cough frequency (number of coughs per hour) in patients with TB has only been studied once, in 1969. The main aim of this study is to describe cough frequency patterns before and after the start of TB treatment and to determine baseline factors that affect cough frequency in these patients. Secondarily, we will evaluate the correlation between cough frequency and TB microbiological resolution. Methods: This study will select participants with culture confirmed TB from 2 tertiary hospitals in Lima, Peru. We estimated that a sample size of 107 patients was sufficient to detect clinically significant changes in cough frequency. Participants will initially be evaluated through questionnaires, radiology, microscopic observation drug susceptibility broth TB-culture, auramine smear microscopy and cough recordings. This cohort will be followed for the initial 60 days of anti-TB treatment, and throughout the study several microbiological samples as well as 24 h recordings will be collected. We will describe the variability of cough episodes and determine its association with baseline laboratory parameters of pulmonary TB. In addition, we will analyse the reduction of cough frequency in predicting TB cure, adjusted for potential confounders. Ethics and dissemination: Ethical approval has been obtained from the ethics committees at each participating hospital in Lima, Peru, Asociación Benéfica PRISMA in Lima, Peru, the Universidad Peruana Cayetano Heredia in Lima, Peru and Johns Hopkins University in Baltimore, USA. We aim to publish and disseminate our findings in peer-reviewed journals. We also expect to create and maintain an online repository for TB cough sounds as well as the statistical analysis employed.
URI : http://cybertesis.uni.edu.pe/handle/uni/3546
ISSN : 20446055
Correo electrónico : rgilman@jhsph.edu
gilmanbob@gmail.com
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones: Instituto General de Investigación

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